TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4Cells released from primary tumors seed metastasesto specific organs by a nonrandomprocess, implyingthe involvement of biologically selective mechanisms.Based on clinical, functional, and molecularevidence, w ...

Lipid signalling in diseaseSignalling lipids such as eicosanoids, phosphoinositides, sphingolipids and fatty acids control important cellular processes, including cell proliferation, apoptosis, metabolism and migration. Extracellular signals from cytokines, growth factors and nutrients control the ...

Elevated tRNAiMet Synthesis Can Drive Cell Proliferation and Oncogenic TransformationCharacteristics of transformed and tumor cellsinclude increased levels of protein synthesis andelevated expression of RNA polymerase (pol) IIIproducts, such as tRNAs and 5S rRNA. However,whether deregula ...